Great Britain Reduction and Inactivation of Superoxide Dismutase by Hydrogen Peroxide By ROBERT C . BRAY

نویسندگان

  • ROBERT C. BRAY
  • STEPHEN A. COCKLE
  • MARTIN FIELDEN
  • PETER B. ROBERTS
  • LILIA CALABRESE
چکیده

By ROBERT C. BRAY and STEPHEN A. COCKLE School ofMolecular Sciences, University ofSussex, Falmer, Brighton BN1 9QJ, Sussex, U.K. and E. MARTIN FIELDEN and PETER B. ROBERTS Division ofPhysics, Institute of Cancer Research, Clifton Avenue, Sutton, Surrey, U.K. and GIUSEPPE ROTILIO and LILIA CALABRESE Centro di Biological Molecolare del C.N. R., Istituto di Chimica Biologica, Universita di Roma, Roma, Italy

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity.

The free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevi...

متن کامل

Superoxide dismutase (SOD) catalyses the conversion of the superoxide radical to hydrogen peroxide and oxygen (McCord

oxygen species that are known to induce the peroxidation of polyunsaturated lipids in cell membranes and to cause degradation of structural proteins, enzymes and ribonucleic acids. These reactive intermediates of oxygen metabolism are converted mainly into molecular oxygen and water by antioxidant enzymes and normally are kept to a minimum in blood and organ tissues (Fridovich, 1978; Fridovich ...

متن کامل

Univalent reduction of molecular oxygen by spinach chloroplasts on illumination.

Spinach chloroplasts induced the photoreduction of cytochrome c and photooxidation of epinephrine, both of which depended on oxygen and were inhibited by superoxide dismutase. This confirmed the univalent reduction of molecular oxygen in illuminated chloroplasts. In the presence of cytochrome c, hydrogen peroxide formation by chloroplasts was inhibited completely. Rates for the photoreduction o...

متن کامل

Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase.

Accompanying the autoxidation of hydroxylamine at pH 10.2, nitroblue tetrazolium was reduced and nitrite was produced in the presence of EDTA. The rate of at&oxidation was negligible below pH 8.0, but sharply increased with increasing pH. The reduction of nitroblue tetrazolium was inhibited by euperoxide dismutaee, indicating the participation of superoxide anion radical in the autoxidation. Hy...

متن کامل

Modifying superoxide dismutase for improved biopharmaceutical properties

The superoxide dismutase enzyme (SOD) contributes to the physiological equilibrium between pro-oxidants and antioxidants, by destroying the superoxide anion (O2). However, its therapeutic use is limited by its fast clearance from the bloodstream and inactivation by its own reaction product, i.e. hydrogen peroxide. Here is a summary of the main strategies developed to circumvent these limitation...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005